COMBINATION THERAPY - PHOTOCHEMOTHERAPY ELECTRIC-CURRENT AND IONIZING-RADIATION - DIFFERENT COMBINATIONS STUDIED IN A WIDR HUMAN COLON ADENOCARCINOMA CELL-LINE

被引：14

作者：

MA, LW ^{[1
]}

IANI, V ^{[1
]}

MOAN, J ^{[1
]}

机构：

[1] INST CANC RES,DEPT BIOPHYS,MONTEBELLO,N-0310 OSLO,NORWAY

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1993年 / 21卷 / 2-3期

关键词：

PHOTOCHEMOTHERAPY; IONIZING RADIATION; ELECTRICITY; PHOTOFRIN-II;

D O I：

10.1016/1011-1344(93)80177-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interactions of pairs of the modalities Photofrin II-sensitized photochemotherapy (PCT), ionizing radiation and an electric current were investigated by the colony formation assay in WiDr cells, a human colon adenocarcinoma cell line. When the cells were treated simultaneously with PCT and an electric current, a slightly synergistic effect was observed at low exposures (surviving fraction approximately 0.1) while a seemingly antagonistic effect was found at higher exposures. The same was found to be true for the combinations of PCT plus ionizing radiation and ionizing radiation plus electric current.

引用

页码：149 / 154

页数：6

共 25 条

[1] PHOTODYNAMIC INACTIVATION OF PSEUDORABIES VIRUS WITH METHYLENE-BLUE DYE, LIGHT, AND ELECTRICITY [J].

BADYLAK, JA ;

SCHERBA, G ;

GUSTAFSON, DP .

JOURNAL OF CLINICAL MICROBIOLOGY, 1983, 17 (02) :374-376

[2] HEMATOPORPHYRIN DERIVATIVE PHOTOSENSITIZATION AND GAMMA-RADIATION DAMAGE INTERACTION IN CHINESE-HAMSTER OVARY FIBROBLASTS [J].

BELLNIER, DA ;

DOUGHERTY, TJ .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1986, 50 (04) :659-664

[3]

BERG K, 1988, LIGHT BIOL MED, V1, P95

[4] SYNERGISM BETWEEN ELECTROLYSIS AND METHYLENE-BLUE PHOTODYNAMIC-ACTION IN ESCHERICHIA-COLI [J].

CAPELLA, MAM ;

MENEZES, S .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1992, 62 (03) :321-326

[5] SYNERGISM BETWEEN ELECTRICITY AND IONIZING-RADIATION [J].

CAPELLA, MAM ;

FONSECA, MEF ;

MENEZES, S .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1991, 8 (04) :371-383

[6]

DOUGHERTY TJ, 1985, CLIN CHEST MED, V6, P219

[7] ELECTROLYTIC UNIVALENT REDUCTION OF OXYGEN IN AQUEOUS-SOLUTION DEMONSTRATED WITH SUPEROXIDE DISMUTASE [J].

FORMAN, HJ ;

FRIDOVIC.I .

SCIENCE, 1972, 175 (4019) :339-&

[8]

GRASCHEW G, 1986, Lasers in Medical Science, V1, P193, DOI 10.1007/BF02040237

[9] HOW DOES PHOTODYNAMIC THERAPY WORK [J].

HENDERSON, BW ;

DOUGHERTY, TJ .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1992, 55 (01) :145-157

[10]

JORI G, 1987, PHOTOBIOCH PHOTO S, P373

← 1 2 3 →