QUANTITATIVE TRAIT LOCUS ANALYSIS OF SUSCEPTIBILITY TO DIET-INDUCED ATHEROSCLEROSIS IN RECOMBINANT INBRED MICE

被引：21

作者：

HYMAN, RW

FRANK, S

WARDEN, CH

DALUISKI, A

HELLER, R

LUSIS, AJ

机构：

[1] UNIV CALIF LOS ANGELES,DEPT MED,DIV CARDIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT MICROBIOL & MOLEC GENET,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

[4] SYNTEX INC,RES,PALO ALTO,CA 94304

来源：

BIOCHEMICAL GENETICS | 1994年 / 32卷 / 11-12期

关键词：

QUANTITATIVE TRAIT LOCUS ANALYSIS; AORTIC FATTY STREAKS; APOLIPOPROTEINS; RECOMBINANT INBRED MICE;

D O I：

10.1007/BF00566060

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (ape A-II). QTL analysis revealed a significant locus on chromosome I distal impacting serum apo A-II concentration on a high-far diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumably Apoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus.

引用

页码：397 / 407

页数：11

共 19 条

[1] Bachorik P S, 1986, Methods Enzymol, V129, P78
[2] LIPOPROTEIN LEVELS IN GENETICALLY SELECTED MICE WITH INCREASED SUSCEPTIBILITY TO ATHEROSCLEROSIS
BRECKENRIDGE, WC
ROBERTS, A
KUKSIS, A
[J]. ARTERIOSCLEROSIS, 1985, 5 (03): : 256 - 264
[3] LEBOEUF RC, 1990, J LIPID RES, V31, P91
[4] LEBOEUF RC, 1983, J BIOL CHEM, V258, P5071
[5] LUSIS AJ, 1983, J BIOL CHEM, V258, P5071
[6] RI MANAGER, A MICROCOMPUTER PROGRAM FOR ANALYSIS OF DATA FROM RECOMBINANT INBRED STRAINS
MANLY, KF
ELLIOTT, RW
[J]. MAMMALIAN GENOME, 1991, 1 (02) : 123 - 126
[7] INFLUENCE OF THE APOA-II GENE LOCUS ON HDL LEVELS AND FATTY STREAK DEVELOPMENT IN MICE
MEHRABIAN, M
QIAO, JH
HYMAN, R
RUDDLE, D
LAUGHTON, C
LUSIS, AJ
[J]. ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (01): : 1 - 10
[8] GENETIC-ANALYSIS OF MURINE STRAINS C57BL/6J AND C3H-HEJ TO CONFIRM THE MAP POSITION OF ATH-1, A GENE DETERMINING ATHEROSCLEROSIS SUSCEPTIBILITY
PAIGEN, B
ALBEE, D
HOLMES, PA
MITCHELL, D
[J]. BIOCHEMICAL GENETICS, 1987, 25 (7-8) : 501 - 511
[9] VARIATION IN SUSCEPTIBILITY TO ATHEROSCLEROSIS AMONG INBRED STRAINS OF MICE
PAIGEN, B
MORROW, A
BRANDON, C
MITCHELL, D
HOLMES, P
[J]. ATHEROSCLEROSIS, 1985, 57 (01) : 65 - 73
[10] ATHEROSCLEROSIS SUSCEPTIBILITY DIFFERENCES AMONG PROGENITORS OF RECOMBINANT INBRED STRAINS OF MICE
PAIGEN, B
ISHIDA, BY
VERSTUYFT, J
WINTERS, RB
ALBEE, D
[J]. ARTERIOSCLEROSIS, 1990, 10 (02): : 316 - 323

← 1 2 →