A POTENT COMPETITIVE INHIBITOR OF 5-HYDROXY-TRYPTAMINE - 3-(2'-BENZYLAMINOETHYL)-5-METHOXYINDOL HYDROCHLORIDE

被引：9

作者：

TAKAGI, K

TAKAYANAGI, I

IRIKURA, T

NISHINO, K

ITO, M

OHKUBO, H

ICHINOSE.N

机构：

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, University of Tokyo, Bunkyo-ku, Tokyo

[2] Department of Chemical Pharmacology, Kyorin Chemical Laboratory, Kita-ku, Tokyo

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1969年 / 19卷 / 02期

关键词：

D O I：

10.1254/jjp.19.234

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

During works on anti-5-hydroxytryptamine activity of tryptamine derivatives, 3-(2'-benzylaminoethyl)-5-methoxyindol hydrochloride (S-8) of which a chemical structure is shown in Chart 1 has been found to be a potent competitive inhibitor of 5-hydroxytryptamine (HT) action on the fundus of the isolated rat stomach, the isolated guinea pig uterus and the isolated guinea pig taenia caecum (taenia coli). It has been also found that S-8 depresses a rise of blood pressure of the rat caused by HT. © 1969, The Japanese Pharmacological Society. All rights reserved.

引用

页码：234 / +

页数：1

共 7 条

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