SPECTROPHOTOMETRIC DETERMINATION OF TOLBUTAMIDE, THIAMINE HYDROCHLORIDE, AND PYRIDOXINE HYDROCHLORIDE IN COMBINATION PRODUCTS

被引：14

作者：

ELSAYED, MA ^{[1
]}

BELAL, SF ^{[1
]}

ELWALILY, AFM ^{[1
]}

ABDINE, H ^{[1
]}

机构：

[1] UNIV ALEXANDRIA,FAC PHARM,ALEXANDRIA,EGYPT

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 06期

关键词：

Antidiabetic agents—tolbutamide; spectrophotometric analysis; in combination tablets; Pyridoxine—analysis; combination tablets with thiamine and tolbutamide; spectrophotometry; first derivative curve; Spectrophotometry—analysis; tolbutamide in combination tablets; Thiamine—analysis; combination tablets with tolbutamide and pyridoxine; Tolbutamide—analysis; combination tablets with thiamine and pyroxidine;

D O I：

10.1002/jps.2600680623

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The first derivative curve is used for tolbutamide determination in unit‐dose tablets and in combination products. The absorbance contribution from tablet excipient and coexisting components, thiamine and pyridoxine, is thereby nullified. The interference from tolbutamide during thiamine and pyridoxine determination is eliminated by solvent extraction and pH‐induced differential spectrophotometry. Thiamine is measured at the isosbestic point of pyridoxine. The latter is determined by the differential absorbance measurement at two wavelengths with the consequent computation of the delta absorbance value. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：739 / 741

页数：3

共 18 条

[1]

AULINERDTMAN G, 1955, CHEMY IND, V74, P581

[2]

CAPEK K, 1958, Pharm Acta Helv, V33, P163

[3]

CLAYTON AW, 1966, J PHARM SCI, V55, P5

[4]

ELSAYED MA, 1977, ACTA PHARM JUGOSL, V27, P161