EFFECT OF A NOVEL ANTICONVULSANT, ZONISAMIDE (AD-810, CI-912), IN AN EXPERIMENTAL-MODEL OF PHOTOSENSITIVE EPILEPSY

被引：6

作者：

WADA, Y

HASEGAWA, H

YAMAGUCHI, N

机构：

[1] Department of Neuropsychiatry, Kanazawa University School of Medicine, Kanazawa

来源：

EPILEPSY RESEARCH | 1990年 / 7卷 / 02期

关键词：

Anticonvulsant; Epilepsy; Kindling; Lateral geniculate body; Photosensitivity;

D O I：

10.1016/0920-1211(90)90096-E

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effects of a novel anticonvulsant, zonisamide (3-sulfamoylmethyl-1,2-benzisoxazole), on photically induced seizures were studied in the lateral geniculate-kindled cat. Zonisamide was found to reduce the behavioral severity of seizure responses to photic stimulation in a dose-related manner. This anticonvulsant effect was only observed with doses that caused behavioral toxicity, but anticonvulsant action outlasted behavioral effects. The present results suggest that zonisamide may be effective in the treatment of human photosensitive epilepsy. © 1990.

引用

页码：117 / 120

页数：4

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