CAPSULATION GENE LOSS AND RESCUE MUTATIONS DURING THE CAP+ TO CAP- TRANSITION IN HAEMOPHILUS-INFLUENZAE TYPE-B

被引:9
作者
BROPHY, LN [1 ]
KROLL, JS [1 ]
FERGUSON, DJP [1 ]
MOXON, ER [1 ]
机构
[1] JOHN RADCLIFFE HOSP,NUFFIELD DEPT PATHOL,OXFORD OX3 9DU,ENGLAND
来源
JOURNAL OF GENERAL MICROBIOLOGY | 1991年 / 137卷
关键词
D O I
10.1099/00221287-137-11-2571
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Genes for Haemophilus influenzae type b capsule expression are duplicated to form a potentially unstable structure, cap, of directly-repeated chromosomal regions of approximately 17 kb. Capsule-deficient mutants arise in a two-stage process, initiated by rec-dependent reduction of this region from two copies to one. This recombinational event is usually lethal, only about 1/200 surviving to form slow-growing colonies of organisms that continue to synthesize polysaccharide but are defective in its export. A variety of secondary 'rescue' mutations within cap can occur to reduce polysaccharide synthesis and restore normal organism appearance and colony morphology.
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页码:2571 / 2576
页数:6
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