THE GM-PI LINKAGE IN 843 FRENCH FAMILIES - EFFECT OF THE ALLELES PI-Z AND PI-S

被引：7

作者：

BABRON, MC ^{[1
]}

CONSTANS, J ^{[1
]}

DUGOUJON, JM ^{[1
]}

CAMBONTHOMSEN, A ^{[1
]}

BONAITIPELLIE, C ^{[1
]}

机构：

[1] HOP PURPAN,CNRS,CTR RECH POLYMORPHISM GENET POPULAT HUMAINES,TOULOUSE,FRANCE

来源：

ANNALS OF HUMAN GENETICS | 1990年 / 54卷

关键词：

D O I：

10.1111/j.1469-1809.1990.tb00366.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Linkage analysis was performed between Gm and Pi in 843 French families. The overall recombination fraction is equal to025 with a sex difference ratio of 1–4 (recombination fraction of 020 in males and 0–29 in females), confirming previous results in the literature. Our study does not confirm the existence of a heterogeneity in recombination rate of Pi S versus non‐S alleles, but it confirms the previous finding that the presence of the Pi Z allele tends to decrease the recombination rate between the two loci. This decrease appears to be similar in both sexes, and not uniquely in males as previously noted. This result suggests a possible linkage disequilibrium between the Pi Z allele and a presumably large inversion between the two loci Gm and Pi. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：107 / 113

页数：7

共 15 条

[1]

BLANC M, 1986, C INSERM, V142, P207

[2]

CHAPUISCELLIER C, 1981, J IMMUNOGENET, V8, P257

[3] PREFERENTIAL TRANSMISSION OF THE Z-DEFICIENT ALLELE OF ALPHA-1-ANTITRYPSIN [J].

CHAPUISCELLIER, C ;

ARNAUD, P .

SCIENCE, 1979, 205 (4404) :407-408

[4]

CONSTANS J, 1982, AM J HUM GENET, V34, P674

[5]

CONSTANS J, 1986, GENETIQUE POPULATION, V142, P227

[6]

COX DW, 1980, AM J HUM GENET, V32, P455

[7] GENES FOR IMMUNOGLOBULIN HEAVY-CHAINS AND FOR ALPHA-1-ANTITRYPSIN ARE LOCALIZED TO SPECIFIC REGIONS OF CHROMOSOME-14Q [J].

COX, DW ;

MARKOVIC, VD ;

TESHIMA, IE .

NATURE, 1982, 297 (5865) :428-431

[8]

GEDDEDAHL T, 1975, ANN HUM GENET, V39, P43

[9]

GEDDEDAHL T, 1981, ANN HUM GENET, V45, P143

[10]

GEDDEDAHL T, 1972, ANN HUM GENET, V35, P393

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