RECOGNITION BY CLASS-II ALLOREACTIVE T-CELLS OF PROCESSED DETERMINANTS FROM HUMAN SERUM-PROTEINS

被引：74

作者：

PANINABORDIGNON, P

CORRADIN, G

ROOSNEK, E

SETTE, A

LANZAVECCHIA, A

机构：

[1] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND

[2] CYTEL,LA JOLLA,CA 92037

[3] UNIV LAUSANNE,INST BIOCHEM,CH-1066 EPALINGES,SWITZERLAND

来源：

SCIENCE | 1991年 / 252卷 / 5012期

关键词：

D O I：

10.1126/science.1710827

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alloreactive T cells recognize a complex composed of an allogeneic major histocompatibility complex (MHC) molecule and a peptide derived from the processing of nonpolymorphic proteins. A sizable fraction of MHC class II alloreactive T cells is shown to recognize peptides derived from constitutive processing of human serum proteins. One such epitope is a fragment of human serum albumin. This epitope bound selectively to the human class II molecule DRw11 and was constitutively present on antigen-presenting cells in vivo. These data indicate that, in the case of MHC class II, peptides involved in allorecognition may originate from exogenous proteins.

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页码：1548 / 1550

页数：3

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