METOCLOPRAMIDE DECREASES APOMORPHINE-INDUCED YAWNING AND PENILE ERECTION

被引：11

作者：

HEATON, JPW ^{[1
]}

VARRIN, SJ ^{[1
]}

机构：

[1] QUEENS UNIV,FAC MED,HUMAN SEXUAL GRP,KINGSTON K7L 2V7,ONTARIO,CANADA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 04期

基金：

英国医学研究理事会;

关键词：

IMPOTENCE; METOCLOPRAMIDE; APOMORPHINE; YAWNING; DOPAMINE;

D O I：

10.1016/0091-3057(91)90264-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Acute administration of metoclopramide, a dopamine (D2) antagonist, reduced both apomorphine-induced yawning and penile erections. Metoclopramide, prominent in clinical use as an effective antiemetic, has been shown to be associated with decreased erectile function in humans. Experimentally naive rats were given a standardized dose of apomorphine and one of a range of doses of metoclopramide. The study shows that metoclopramide decreases the erectile response to apomorphine and suggests that the erectile difficulties experienced in humans after metoclopramide treatment may be a result of interference with a central dopaminergic mechanism(s).

引用

页码：917 / 920

页数：4

共 34 条

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