THE EFFECT OF TETRABUTYLAMMONIUM ION ON CHICKEN BRAIN ACETYLCHOLINESTERASE ACTIVITY INVITRO

被引：13

作者：

ALJAFARI, AA

机构：

[1] Department of Biochemistry, College of Science, King Saud University, Riyadh, 11451

来源：

DRUG AND CHEMICAL TOXICOLOGY | 1992年 / 15卷 / 04期

关键词：

D O I：

10.3109/01480549209014159

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of tetrabutylammonium ion on chicken brain acetylcholinesterase activity was investigated. Tetrabutylammonium ion (1-4mM) reversibly inhibited acetylcholinesterase activity of chicken brain (34-73%) in a concentration dependent manner, the IC50 being about 1.1mM. A Lineweaver-Burk plot, as well as a Dixon plot, indicated that the nature of inhibition is noncompetitive with a Km value of 0.134mM and a Ki value of 1.58mM at 37-degrees-C. An Arrhenius plot showed that the transition temperature is significantly reduced in the presence of tetrabutylammonium ion.

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页码：295 / 312

页数：18

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