UTILITY OF GENE REARRANGEMENTS IN LYMPHOID MALIGNANCIES

被引：20

作者：

AISENBERG, AC

机构：

[1] Hematology/Oncology Unit, Department of Medicine, Massachusetts General Hospital, Boston

来源：

ANNUAL REVIEW OF MEDICINE | 1993年 / 44卷

关键词：

IMMUNOGLOBULIN GENE REARRANGEMENTS; T-CELL RECEPTOR GENE REARRANGEMENTS; LYMPHOMA; LYMPHOCYTIC LEUKEMIA;

D O I：

10.1146/annurev.me.44.020193.000451

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Molecular genetic study of lymphoid neoplasms by Southern blotting or polymerase chain reaction permits the ready detection of gene rearrangements. Clonal rearrangements of immunoglobulin and T-cell receptor genes identify neoplasms of B- and T-cell lineage, respectively. Additionally, lymphoma-specific chromosome translocations involving oncogenes are detected with the same molecular techniques. Probes are currently available to study the c-myc translocations of Burkitt's lymphoma, the bcl-2 translocations of follicular lymphomas, and the bcl-1 translocations of centrocytic lymphoma.

引用

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页码：75 / 84

页数：10

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