GROWTH IN GROWTH-HORMONE INSENSITIVITY

被引：29

作者：

ROSENBLOOM, AL

GUEVARAAGUIRRE, J

ROSENFELD, RG

POLLOCK, BH

机构：

[1] INST ENDOCRINOL METAB & REPROD,QUITO,ECUADOR

[2] OREGON HLTH SCI UNIV,DEPT PEDIAT,PORTLAND,OR 97403

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 07期

关键词：

D O I：

10.1016/1043-2760(94)P3205-L

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect even in a genetically homogeneous population is partly explained by correlation of so score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH ave not necessary for these responses.

引用

页码：296 / 303

页数：8

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