BIOSYNTHETIC-PATHWAY FOR A NEW SERIES OF GANGLIOSIDES, GT1A-ALPHA AND GQ1B-ALPHA

被引：17

作者：

IRIE, F

HIDARI, KIPJ

TAI, T

LI, YT

SEYAMA, Y

HIRABAYASHI, Y

机构：

[1] INST PHYS & CHEM RES,GLYCO CELL BIOL LAB,FRONTIER RES PROGRAM,WAKO,SAITAMA 35101,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT PHYSIOL CHEM & NUTR,BUNKYO KU,TOKYO 113,JAPAN

[3] TOKYO METROPOLITAN INST MED SCI,DEPT TUMOR BIOL,BUNKYO KU,TOKYO 113,JAPAN

[4] TULANE UNIV,SCH MED,DEPT BIOCHEM,NEW ORLEANS,LA 70112

来源：

FEBS LETTERS | 1994年 / 351卷 / 02期

关键词：

GANGLIOSIDE; SIALYLTRANSFERASE; GANGLIOSIDE BIOSYNTHESIS; CHOLINERGIC NEURON-SPECIFIC ANTIGEN;

D O I：

10.1016/0014-5793(94)00883-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new class of gangliosides, GT1a alpha and GQ1b alpha, were initially identified as cholinergic neuron-specific antigens in bovine brain. These gangliosides have in common alpha 2-6 NeuAc linked to the GalNAc residue in the gangliotetraose core structure. In this study, we have determined the biosynthetic pathways of GT1a alpha and GQ1b alpha using rat liver Golgi fraction. The results showed that GT1a alpha and GQ1b alpha were synthesized from GD1a and GT1b, respectively, by the action of a GalNAc alpha 2-6 sialyltransferase. It was also demonstrated that these two gangliosides were found to exist as extremely minor components in rat liver.

引用

页码：291 / 294

页数：4

共 24 条

[1] A TRISIALOGANGLIOSIDE CONTAINING A SIALYL ALPHA-2-6 N-ACETYLGALACTOSAMINE RESIDUE IS A CHOLINERGIC-SPECIFIC ANTIGEN, CHOL-1-ALPHA [J].