PREVALENCE OF IGM ANTIBODIES TO HUMAN HERPESVIRUS-6 EARLY ANTIGEN (P41/38) IN PATIENTS WITH CHRONIC FATIGUE SYNDROME

被引：62

作者：

PATNAIK, M

KOMAROFF, AL

CONLEY, E

OJOAMAIZE, EA

PETER, JB

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,BOSTON,MA 02115

[2] CHRON FATIGUE SYNDROME CLIN,FLINT,MI

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 05期

关键词：

D O I：

10.1093/infdis/172.5.1364

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To evaluate the association between human herpesvirus 6 (HHV-6) and chronic fatigue syndrome (CFS), 2 geographically separate groups of CFS patients (125 and 29 patients, respectively) and healthy controls (150 and 15 controls, respectively) were compared, using an EIA, for antibodies to HHV-6 early antigen p41/38 (EA), Sixty percent (93/154) of CFS patients were positive for HHV-6 EA IgM, 40% (61/154) were positive for IgG, and 23% (35/154) were positive for both, A total of 119 (77%) of the CFS patients were positive for HHV-6 EA Ige or IgM (or both); only 12% (20/165) of the controls had IgG or IgM to HHV-6 EA. These data demonstrate that more CFS patients than controls had elevated levels of HHV-6 EA-specific IgM, perhaps indicating active replication of HHV-6 in CFS.

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页码：1364 / 1367

页数：4

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