DIRECT ENANTIOMERIC SEPARATION OF SATERINONE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：11

作者：

RUDOLPH, M

机构：

[1] Beiersdorf AG, R and D Pharma, Biochemical Department, D-2000 Hamburg 20

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 525卷 / 01期

关键词：

D O I：

10.1016/S0378-4347(00)83389-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new method is described for the direct liquid chromatographic separation and determination of the enantiomers of saterinone, 1-[(4-cyano-1,2-dihydro-6-methyl-2-oxopyridinyl-5)-phenoxy]-3-[4-(2-methoxyphenyl)piperazinyl-1]-propan-2-ol, using a Chiralcel OD™ column with methanol as eluent and a temperature set to 10°C. Several lots of synthesized enantiomers were analysed for their enantiomeric purity of more than 99%, because of the excellent resolution (Rs=2.2). Furthermore the enantiomeric ratio was determined in plasma samples after oral and intravenous administration of racemic saterinone. © 1990.

引用

收藏

页码：161 / 168

页数：8

相关论文

共 12 条

[1]

ARMAH BI, 1988, DRUG RES, V9, P1287

[2] SEPARATION OF AMINO-ACID ENANTIOMERS AND CHIRAL AMINES USING PRECOLUMN DERIVATIZATION WITH (+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE AND REVERSED-PHASE LIQUID-CHROMATOGRAPHY [J].

EINARSSON, S ;

JOSEFSSON, B ;

MOLLER, P ;

SANCHEZ, D .

ANALYTICAL CHEMISTRY, 1987, 59 (08) :1191-1195

[3] RESOLUTION OF THE ENANTIOMERS OF EPHEDRINE, NOREPHEDRINE AND PSEUDOEPHEDRINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

GAL, J .

JOURNAL OF CHROMATOGRAPHY, 1984, 307 (01) :220-223

[4] DIRECT ENANTIOMERIC SEPARATION OF BETAXOLOL WITH APPLICATIONS TO ANALYSIS OF BULK DRUG AND BIOLOGICAL SAMPLES [J].

KRSTULOVIC, AM ;

FOUCHET, MH ;

BURKE, JT ;

GILLET, G ;

DURAND, A .

JOURNAL OF CHROMATOGRAPHY, 1988, 452 :477-483

[5] CHIRAL STATIONARY PHASES FOR THE LIQUID-CHROMATOGRAPHIC SEPARATION OF PHARMACEUTICALS [J].

KRSTULOVIC, AM .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1988, 6 (6-8) :641-656

[6] DIRECT SEPARATION OF DRUG ENANTIOMERS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH CHIRAL STATIONARY PHASES [J].

MEHTA, AC .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 426 (01) :1-13

[7] OPTICAL RESOLUTION OF RACEMIC DRUGS BY CHIRAL HPLC ON CELLULOSE AND AMYLOSE TRIS(PHENYLCARBAMATE) DERIVATIVES [J].

OKAMOTO, Y ;

ABURATANI, R ;

HATANO, K ;

HATADA, K .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1988, 11 (9-10) :2147-2163

[8] DETERMINATION OF SATERINONE IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

RUDOLPH, M .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1989, 497 :342-348

[9] RESOLUTION OF THE ENANTIOMERS OF PROPRANOLOL AND OTHER BETA-ADRENERGIC ANTAGONISTS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

SEDMAN, AJ ;

GAL, J .

JOURNAL OF CHROMATOGRAPHY, 1983, 278 (01) :199-203

[10] CHROMATOGRAPHIC OPTICAL RESOLUTION ON POLYSACCHARIDES AND THEIR DERIVATIVES [J].

SHIBATA, T ;

OKAMOTO, I ;

ISHII, K .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1986, 9 (2-3) :313-340