THE LAKE CASITAS WILD MOUSE - EVOLVING GENETIC-RESISTANCE TO RETROVIRAL DISEASE

被引:77
作者
GARDNER, MB
KOZAK, CA
OBRIEN, SJ
机构
[1] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892
[2] NCI,FREDERICK CANC RES FACIL,OTOLARYNGOL LAB,FREDERICK,MD 21701
关键词
D O I
10.1016/0168-9525(91)90017-K
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A small colony of feral mice from California continues to flourish in spite of a virulent epizootic of pathological retrovirus. Epidemiological and genetic studies revealed that the viral infection is strongly balanced by the polymorphic resistance locus, Fv-4, a transcriptionally active but truncated provirus that originated in the East Asian ancestors of the Californian mice. The natural history of these populations represents a graphic example of genomic adaptation in free-ranging populations to regulate and delimit infectious disease.
引用
收藏
页码:22 / 27
页数:6
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