THE LAKE CASITAS WILD MOUSE - EVOLVING GENETIC-RESISTANCE TO RETROVIRAL DISEASE

被引：77

作者：

GARDNER, MB

KOZAK, CA

OBRIEN, SJ

机构：

[1] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892

[2] NCI,FREDERICK CANC RES FACIL,OTOLARYNGOL LAB,FREDERICK,MD 21701

来源：

TRENDS IN GENETICS | 1991年 / 7卷 / 01期

关键词：

D O I：

10.1016/0168-9525(91)90017-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A small colony of feral mice from California continues to flourish in spite of a virulent epizootic of pathological retrovirus. Epidemiological and genetic studies revealed that the viral infection is strongly balanced by the polymorphic resistance locus, Fv-4, a transcriptionally active but truncated provirus that originated in the East Asian ancestors of the Californian mice. The natural history of these populations represents a graphic example of genomic adaptation in free-ranging populations to regulate and delimit infectious disease.

引用

页码：22 / 27

页数：6

共 33 条

[1] ANALYSIS OF ENDOGENOUS AVIAN RETROVIRUS DNA AND RNA - VIRAL AND CELLULAR DETERMINANTS OF RETROVIRUS GENE-EXPRESSION [J].