REQUIREMENT FOR ESCHERICHIA-COLI NUSG PROTEIN IN FACTOR-DEPENDENT TRANSCRIPTION TERMINATION

被引：172

作者：

SULLIVAN, SL

GOTTESMAN, ME

机构：

[1] Institute of Cancer Research College of Physicians, Surgeons Columbia University New York

来源：

CELL | 1992年 / 68卷 / 05期

关键词：

D O I：

10.1016/0092-8674(92)90041-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 21 kd NusG protein is essential for E. coli viability. Cells depleted for NusG were defective for factor-dependent transcription termination. Rho-induced polarity in the gal operon and the Rho-dependent lambda-tR1 and lambda-tL1 terminators were suppressed in NusG-deficient cells. NusG depletion inactivated the phage HK022 Nun termination factor. In contrast, the factor-independent lambda-tl terminator was fully active in NusG-depleted cells and could be suppressed by phage lambda-N function.

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页码：989 / 994

页数：6

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