P-GLYCOPROTEIN-MEDIATED RENAL TUBULAR SECRETION OF DIGOXIN - THE TOXICOLOGICAL SIGNIFICANCE OF THE URINE-BLOOD BARRIER MODEL

被引：19

作者：

ITO, S ^{[1
]}

WOODLAND, C ^{[1
]}

HARPER, PA ^{[1
]}

KOREN, G ^{[1
]}

机构：

[1] HOSP SICK CHILDREN,RES INST,DEPT PEDIAT,DIV CLIN PHARMACOL & TOXICOL,555 UNIV AVE,TORONTO M5G 1X8,ONTARIO,CANADA

来源：

LIFE SCIENCES | 1993年 / 53卷 / 02期

关键词：

D O I：

10.1016/0024-3205(93)90667-R

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We provide direct evidence that verapamil inhibits active digoxin secretion in renal tubular cells (LLC-PK1), and that verapamil increases cellular accumulation of digoxin. These findings suggest that verapamil inhibits the digoxin active secretory transport at the apical membranes, supporting the theory that P-glycoprotein mediates digoxin secretion in the renal tubular cells. Based on existing data on digoxin transport, we present a hypothetical model for the renal handling of digoxin, implying that P-glycoprotein functions as a driving mechanism of a unidirectional ''urine-blood'' barrier.

引用

页码：PL25 / PL31

页数：7

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