INTRAPHAGOCYTIC ACTIVITY OF ERYTHROMYCIN, ROXITHROMYCIN AND AZITHROMYCIN

被引：17

作者：

MILATOVIC, D

机构：

[1] Department of Medical Microbiology, Technical University Munich, Munich 80, 8000

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1990年 / 9卷 / 01期

关键词：

D O I：

10.1007/BF01969530

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The intraphagocytic activity of erythromycin, roxithromycin and azithromycin against phagocytosed Staphylococcus aureus was compared. Erythromycin and roxithromycin both acted bacteriostatically at concentrations corresponding to 10×MIC. Azithromycin, however, did not prevent intracellular proliferation of the staphylococci. On comparison of the pH dependency of the antibacterial activity of the three drugs, azithromycin was found to be inactivated earlier in an acidic milieu. © 1990 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

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页码：33 / 35

页数：3

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