SPIRO-BETA-LACTAMS FROM [2+2]-CYCLOADDITION OF KETENES TO IMINOLACTONES

被引：9

作者：

ROTH, M ^{[1
]}

机构：

[1] CIBA GEIGY AG,ZENT FORSCHUNGSLAB,CH-4002 BASEL,SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1979年 / 62卷 / 06期

关键词：

D O I：

10.1002/hlca.19790620625

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Spiro‐β‐lactams from [2+2]‐Cycloaddition of Ketenes to Iminolactones Iminolactones (‘Isoimides’) derived from maleic anhydride and amines are shown to react with various ketenes in a [2+2]‐cycloaddition mode. Either preformed ketenes or the combination acid chloride/tertiary amine can be used as reagent. The reaction products have been assigned the spiro‐β‐lactam structure. Unsubstituted ketene is inert under the reaction conditions. It is possible to synthesize the spiro‐β‐lactams in a one‐pot procedure, starting from a mixture of maleic anhydride/amine and excess dialkylketene. Copyright © 1979 Verlag GmbH & Co. KGaA, Weinheim

引用

页码：1966 / 1977

页数：12

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