MICE LACKING MHC CLASS-II MOLECULES

被引：776

作者：

COSGROVE, D ^{[1
]}

GRAY, D ^{[1
]}

DIERICH, A ^{[1
]}

KAUFMAN, J ^{[1
]}

LEMEUR, M ^{[1
]}

BENOIST, C ^{[1
]}

MATHIS, D ^{[1
]}

机构：

[1] BASEL INST IMMUNOL, CH-4058 BASEL, SWITZERLAND

来源：

CELL | 1991年 / 66卷 / 05期

关键词：

D O I：

10.1016/0092-8674(91)90448-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have produced mice that lack major histocompatibility complex class II antigens, permitting us to evaluate the role of these molecules in diverse aspects of T and B cell differentiation. The mutant mice show near-complete elimination of CD4+ T lymphocytes from the spleen and lymph nodes; the few remaining CD4-positive cells are preferentially localized to B cell follicles. Surprisingly, substantial numbers of CD4 single-positive cells reside in the thymus; however, these are not mature thymocytes as we currently recognize them. B lymphocytes occur in normal numbers and are capable of terminal differentiation to plasma cells. Nevertheless, several aberrations in the B cell compartment are demonstrable: a lack of germinal centers, fewer IgM+IgD+ cells in certain individuals, reduced production of serum IgG1, and complete inability to respond to T-dependent antigens. In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises.

引用

页码：1051 / 1066

页数：16

共 118 条

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