TRISOMY-12 AND K-RAS-2 AMPLIFICATION IN HUMAN OVARIAN-TUMORS

被引：36

作者：

YANGFENG, TL

LI, SB

LEUNG, WY

CARCANGIU, ML

SCHWARTZ, PE

机构：

[1] NATL YANG MING MED COLL,VET GEN HOSP,DEPT OBSTET & GYNECOL,TAIPEI,TAIWAN

[2] YALE UNIV,SCH MED,DEPT PATHOL,NEW HAVEN,CT 06510

[3] YALE UNIV,SCH MED,DEPT OBSTET & GYNECOL,NEW HAVEN,CT 06510

来源：

INTERNATIONAL JOURNAL OF CANCER | 1991年 / 48卷 / 05期

关键词：

D O I：

10.1002/ijc.2910480508

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis was performed on 11 benign and borderline ovarian tumors. Trisomy 12, identified as a sole abnormality in 6 tumors, is likely a specific karyotypic change in different benign and borderline tumors and may well be a primary chromosomal lesion in these tumors. The possible association between amplification of the proto-oncogene K-ras-2 which is located on chromosome 12 and trisomy 12 was investigated. DNA blotting analysis of 64 tumors indicates that trisomy 12 does not seem to be related to K-ras-2 amplification in ovarian tumors. K-ras-2 amplification was observed in 3 high-grade tumors from 3 patients with metastases.

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页码：678 / 681

页数：4

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