A TRANSDERMAL NICOTINE SYSTEM - FEASIBILITY STUDIES

被引：12

作者：

BERNER, B

MAZZENGA, GC

GARGIULO, PM

STEFFENS, R

机构：

[1] Basic Pharmaceutics Research, CIBA-GEIGY Corporation, Ardsley, NY

来源：

JOURNAL OF CONTROLLED RELEASE | 1992年 / 20卷 / 01期

关键词：

TRANSDERMAL NICOTINE; SKIN PERMEATION; SKIN IRRITATION; SMOKING CESSATION;

D O I：

10.1016/0168-3659(92)90134-D

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The permeation of nicotine through human epidermis in vitro, membranes, adhesives, an adhesive-membrane laminate, and the laminate with epidermis was measured. Skin irritation in rabbits was shown to depend on the driving force of nicotine in the donor phase. A transdermal nicotine system is described that provides substantial control of nicotine entry through skin by a rate-controlling membrane.

引用

页码：13 / 19

页数：7

共 33 条

[1]

ABELIN T, 1989, LANCET, V1, P7

[2]

Badgett C.O., 1947, US Patent, Patent No. [#US 2432642, 2432642]

[3]

BENOWITZ NL, 1985, J PHARMACOL EXP THER, V234, P153

[4]

BENOWITZ NL, 1982, J PHARMACOL EXP THER, V221, P368