EFFECTS OF MAJOR HISTOCOMPATIBILITY COMPLEX ON ANTIBODY-RESPONSE IN F1 AND F2 CROSSES OF CHICKEN LINES

被引：13

作者：

PINARD, MH

VANDERZIJPP, AJ

机构：

[1] AGR UNIV WAGENINGEN,DEPT ANIM HUSB,6700 HB WAGENINGEN,NETHERLANDS

[2] DLO RES INST ANIM PROD SCHOONOORD,ZEIST,NETHERLANDS

来源：

GENETICS SELECTION EVOLUTION | 1993年 / 25卷 / 03期

关键词：

CHICKEN; HUMORAL RESPONSE; SELECTION; CROSS; MAJOR HISTOCOMPATIBILITY COMPLEX;

D O I：

10.1051/gse:19930306

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Lines of chickens selected for 9 generations for high (H) and low (L) antibody (Ab) response to sheep red blood cells (SRBC) were crossed to produce F1 (n = 761) and F2(n = 1033) populations. All animals were typed for major histocompatibility complex (MHC) B-types. Effects of MHC genotypes and haplotypes on the Ab titer to SRBC were estimated. The MHC genotypes and remaining genotype explained 2.5% and 31% of the total variation of the Ab titer in the F2 respectively. Estimates of MHC effects in the F2 were similar to estimates in the selected lines. The 119 and 121 B-haplotypes were associated with a significantly higher response than the 114 and 124 B-haplotypes. These results confirm the hypothesis that changes in B-type distribution observed in the selected lines could be related to a direct or closely linked effect of MHC on the immune response.

引用

页码：283 / 296

页数：14

共 30 条

[1] CLASS-1 ALLELES OF THE BOVINE MAJOR HISTOCOMPATIBILITY SYSTEM AND THEIR ASSOCIATION WITH ECONOMIC TRAITS [J].