PATHOLOGICAL-CHANGES ASSOCIATED WITH TOPICAL CHEMOTHERAPY FOR SUPERFICIAL BLADDER-CANCER

被引:43
作者
MURPHY, WM
SOLOWAY, MS
FINEBAUM, PJ
机构
[1] BAPTIST MEM HOSP, DEPT PATHOL, MEMPHIS, TN 38146 USA
[2] UNIV TENNESSEE, CTR HLTH SCI, DEPT UROL, MEMPHIS, TN 38163 USA
关键词
D O I
10.1016/S0022-5347(17)54576-0
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
With use of previous observations in experimental animals as a basis for comparison, the cytologic and histologic changes in human patients who underwent topical chemotherapy [mitomycin C, thiotepa] for superficial bladder cancer were documented. Despite the potential for inhibition of DNA replication these drugs apparently act in vivo as toxic substances, causing increased exfoliation with denudation of papillary and/or flat urothelium. Multinucleation was common but was confined to superficial cells. Atypical cells, such as those observed after systemic chemotherapy with cyclophosphamide, rarely were present and could be distinguished readily from neoplastic elements. Although topical chemotherapy may suppress tumor growth and progression it apparently does not eradicate the neoplastic process.
引用
收藏
页码:461 / 464
页数:4
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