ASSESSMENT OF BROMHEXINE HYDROCHLORIDE FORMULATIONS IN HUMAN DRY EYE PATIENTS

被引：2

作者：

ELFAHAM, TH ^{[1
]}

MASSOUD, AA ^{[1
]}

机构：

[1] ASSIUT UNIV,FAC OPHTHALMOL,ASSIUT 71516,EGYPT

来源：

JOURNAL OF CONTROLLED RELEASE | 1994年 / 32卷 / 03期

关键词：

D O I：

10.1016/0168-3659(94)90238-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The mucolytic drug bromhexine hydrochloride (BH), was formulated in different ophthalmic dosage forms. The influence of the drug from the different formulations on tear flow rate in humans was investigated. The formulations tested were: BH aqueous solution, methylcellulose and carbopol(934) hydrogels; and two polymeric inserts, namely; Gantrez AN 169 (G) and cellulose acetate (CA). The greatest influence on tear production was found using carbopol(934). Although both polymeric inserts showed less influence than carbopol(934), they sustained the action of BH in the human eye.

引用

页码：279 / 283

页数：5

共 13 条

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