CONCURRENCE OF ALZHEIMERS-DISEASE, PARKINSONS-DISEASE, DIFFUSE LEWY BODY DISEASE, AND AMYOTROPHIC-LATERAL-SCLEROSIS

被引：28

作者：

HEDERA, P

LERNER, AJ

CASTELLANI, R

FRIEDLAND, RP

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT NEUROL,NEUROGENET LAB,CLEVELAND,OH 44106

[2] CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,ALZHEIMER CTR,DEPT NEUROL,CLEVELAND,OH 44106

[3] CASE WESTERN RESERVE UNIV,DIV NEUROPATHOL,CLEVELAND,OH 44106

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1995年 / 128卷 / 02期

关键词：

ALZHEIMERS DISEASE; PARKINSONS DISEASE; DIFFUSE LEWY BODY DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; UBIQUITIN; DEMENTIA;

D O I：

10.1016/0022-510X(94)00222-A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, neurofibrillary tangles, and Lewy bodies in the substantia nigra and neocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions were present in the anterior horns of the spinal cord. Overlapping of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understanding of the process of neurodegeneration.

引用

页码：219 / 224

页数：6

共 49 条

[1] A UNIFYING HYPOTHESIS FOR THE CAUSE OF AMYOTROPHIC LATERAL SCLEROSIS, PARKINSONISM, AND ALZHEIMER-DISEASE [J].