AFFINITY ALKYLATION OF 3-OXO- DELTA-5-STEROID ISOMERASE BY STEROIDAL 3-BETA-OXIRANES - IDENTIFICATION OF THE MODIFIED AMINO-ACID BY REDUCTION WITH HYDROXYBOROHYDRIDE

被引：33

作者：

BOUNDS, PL ^{[1
]}

POLLACK, RM ^{[1
]}

机构：

[1] UNIV MARYLAND,DEPT CHEM,CHEM DYNAM LAB,CATONSVILLE,MD 21228

来源：

BIOCHEMISTRY | 1987年 / 26卷 / 08期

关键词：

D O I：

10.1021/bi00382a029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2263 / 2269

页数：7

共 46 条

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[4] IRREVERSIBLE ACTIVE-SITE-DIRECTED INHIBITION OF DELTA-5-3-KETOSTEROID ISOMERASE BY STEROIDAL 17-BETA-OXIRANES - EVIDENCE FOR 2 MODES OF BINDING IN STEROID-ENZYME COMPLEXES
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[5] MODIFICATION OF AN ENZYME CARBOXYLATE RESIDUE IN THE INHIBITION OF 3-OXO-DELTA-5-STEROID ISOMERASE BY (3S)-SPIRO[5-ALPHA-ANDROSTANE-3,2'-OXIRANE]-17-BETA-OL - IMPLICATIONS FOR THE MECHANISM OF ACTION
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[6] DETECTION OF A TRANSIENT ENZYME STEROID COMPLEX DURING ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITION OF 3-OXO-DELTA-5-STEROID ISOMERASE
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[7] SPECIFIC CLEAVAGE OF PEPTIDES CONTAINING AN ASPARTIC-ACID (BETA-HYDROXAMIC ACID) RESIDUE
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COLLINS, KD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (14) : 4305 - 4313
[8] PARTICIPATION OF ASPARTYL RESIDUES IN HYDROXYLAMINE- OR HYDRAZINE-SENSITIVE BONDS OF COLLAGEN
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[J]. BIOCHEMISTRY, 1962, 1 (06) : 947 - +
[9] BORNSTEIN P, 1970, J BIOL CHEM, V245, P4854
[10] SELECTIVE REDUCTIONS .30. EFFECT OF CATION AND SOLVENT ON THE REACTIVITY OF SALINE BOROHYDRIDES FOR REDUCTION OF CARBOXYLIC ESTERS - IMPROVED PROCEDURES FOR THE CONVERSION OF ESTERS TO ALCOHOLS BY METAL BOROHYDRIDES
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CHOI, YM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (24) : 4702 - 4708

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