CRYOPRESERVED PERIPHERAL-BLOOD CELLS FUNCTIONING AS AUTOGRAFTS IN PATIENTS WITH CHRONIC GRANULOCYTIC-LEUKEMIA IN TRANSFORMATION

被引：79

作者：

GOLDMAN, JM ^{[1
]}

CATOVSKY, D ^{[1
]}

HOWS, J ^{[1
]}

SPIERS, ASD ^{[1
]}

GALTON, DAG ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH, DEPT MED, LONDON W12 0HS, ENGLAND

来源：

BMJ-BRITISH MEDICAL JOURNAL | 1979年 / 1卷 / 6174期

关键词：

D O I：

10.1136/bmj.1.6174.1310

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Six patients with chronic granulocytic leukaemia (CGL) in transformation were treated with cytotoxic drugs or cytotoxic drugs plus total body irradiation, followed by infusion of reconstituted autologous peripheral blood cells that had been collected from them at diagnosis and stored in liquid nitrogen for up to 58 months. In four cases the blood and bone-marrow appearances were rapidly restored to those of typical chronic-phase disease. In three of these patients transformation recurred at 74, 32, and 26 weeks respectively. One patient was still in second chronic phase at eight weeks. One of the patients who entered a second transformation was restored to a third chronic phase by further treatment with cytotoxic drugs and a second autograft. Cryopreserved autologous blood cells may thus restore some patierfts with CGL in transformation to chronic-phase disease and so may help to prolong life. © 1979, British Medical Journal Publishing Group. All rights reserved.

引用

页码：1310 / 1313

页数：4

共 22 条

[1]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P31

[2]

BUCKNER CD, 1978, EXP HEMATOL, V6, P96

[3]

CATOVSKY D, 1978, B I SIEROTER MILAN, V57, P344

[4]

ENNO A, 1978, LANCET, V2, P395

[5] INVITRO COLONY-FORMING CELLS AND COLONY STIMULATING FACTOR IN CHRONIC GRANULOCYTIC LEUKEMIA [J].

GOLDMAN, JM ;

THNG, KH ;

LOWENTHAL, RM .

BRITISH JOURNAL OF CANCER, 1974, 30 (01) :1-12

[6]

GOLDMAN JM, 1978, SEMIN HEMATOL, V15, P420

[7]

GOLDMAN JM, 1978, LANCET, V1, P437

[8] COLLECTION, CRYOPRESERVATION AND SUBSEQUENT VIABILITY OF HEMATOPOIETIC STEM-CELLS INTENDED FOR TREATMENT OF CHRONIC GRANULOCYTIC LEUKEMIA IN BLAST-CELL TRANSFORMATION [J].

GOLDMAN, JM ;

THNG, KH ;

PARK, DS ;

SPIERS, ASD ;

LOWENTHAL, RM ;

RUUTU, T .

BRITISH JOURNAL OF HAEMATOLOGY, 1978, 40 (02) :185-195

[9]

GOLDMAN JM, 1973, CRYOPRESERVATION NOR, P71

[10]

GRAW RG, 1970, LANCET, V2, P338

← 1 2 3 →