ANTI-SCHIZOPHRENIC DRUGS - DIFFERENTIAL PLASMA-PROTEIN BINDING AND THERAPEUTIC ACTIVITY

被引：48

作者：

FREEDBERG, KA

INNIS, RB

CREESE, I

SNYDER, SH

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT EXPTL THERAPEUT,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205

来源：

LIFE SCIENCES | 1979年 / 24卷 / 26期

关键词：

D O I：

10.1016/0024-3205(79)90457-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The percentage of free neuroleptic drug unbound to plasma protein is much higher for the respective metabolites of chlorpromazine and thioridazine, 7-hydroxychlorpromazine and mesoridazine, than for the parent drugs. The therapeutic activities of chlorpromazine and thioridazine may be mediated to a major extent by 7-hydroxychlorpromazine and mesoridazine respectively. Measuring free levels of the active metabolites of neuroleptics as well as the parent drugs may facilitate regulation of neuroleptic doses to secure optimal therapeutic responses. © 1979.

引用

页码：2467 / 2473

页数：7

共 35 条

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