RENAL PERFUSION CHANGES DURING TREATMENT OF ESSENTIAL-HYPERTENSION - PRAZOSIN VERSUS PROPRANOLOL

被引：32

作者：

OCONNOR, DT ^{[1
]}

PRESTON, RA ^{[1
]}

SASSO, EH ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT MED,SAN DIEGO,CA 92110

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1979年 / 1卷 / 06期

关键词：

Hypertension; Prazosin; Propranolol; Renal hemodynamics;

D O I：

10.1097/00005344-197900011-00005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To evaluate renal hemodynamic changes during therapy of essential hypertension, we treated 12 essential hypertensives in crossover fashion, with 1 month each of placebo, prazosin, and propranolol alone. During prazosin treatment, blood pressure was normalized with preservation of glomerular filtration rate, renal plasma flow, and renal blood flow. Propranolol, however, normalized blood pressure with an associated significant decline in glomerular filtration rate, renal plasma flow, and renal blood flow. The potential mechanisms are discussed. © 1979 Raven Press, New York.

引用

页码：S38 / S42

页数：5

共 21 条

[1]

BLISS CI, 1970, STATISTICS BIOL, P558

[2] EFFECT OF NOREPINEPHRINE ISOPROTERENOL AND ADRENERGIC BLOCKERS UPON INTRARENAL DISTRIBUTION OF BLOOD FLOW [J].