RUBBER SOLVENT - CLASTOGENIC AGENT THAT FAILS TO INDUCE SISTER-CHROMATID EXCHANGES

被引：6

作者：

ALTENBURG, LC

RAY, JH

SMART, CE

MOORE, FB

机构：

[1] Medical Genetics Center, The University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences, Houston

来源：

MUTATION RESEARCH | 1979年 / 67卷 / 04期

关键词：

D O I：

10.1016/0165-1218(79)90029-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Rubber solvent was tested for its ability to induce chromosome aberrations and sister-chromatid exchanges in human whole blood cultures. Following exposure to relatively low rubber solvent concentrations (0.0125% and greater) significant increases in the frequencies of chromatid gaps and breaks were observed. At higher rubber-solvent concentrations (0.05% and greater) there were also significant increases in the frequency of chromosome breaks. In contrast to the increase in chromosome aberrations following rubber-solvent exposure, rubber-solvent concentrations up to the toxic level failed to produce increases in the sister-chromatid exchange frequency. © 1979.

引用

页码：331 / 341

页数：11

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