SYNTHESIS OF A POTENTIAL INHIBITOR OF UDP-GLUCURONOSYLTRANSFERASE

被引：10

作者：

NOORT, D

VANSTRATEN, NCR

BOONS, GJPH

VANDERMAREL, GA

BOSSUYT, X

BLANCKAERT, N

MULDER, GJ

VANBOOM, JH

机构：

[1] CATHOLIC UNIV LEUVEN,BIOL CHEM LAB,B-3000 LOUVAIN,BELGIUM

[2] CTR BIOPHARMACEUT SCI,DIV TOXICOL,2300 RA LEIDEN,NETHERLANDS

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81202-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient synthesis of phosphonomethyl 1-O-(2,2,2-triphenyl)ethyl-alpha-D-gluco-2-heptulopyranosiduronate (2) is presented. The target compound proved to be an inhibitor of UDP-glucuronosyltransferase in vitro.

引用

页码：583 / 588

页数：6

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