FACILE ACCESS TO 2'-O-ACYL PRODRUGS OF 1-(BETA-D-ARABINOFURANOSYL)-5(E)-(2-BROMOVINYL)URACIL (BVARAU) VIA REGIOSELECTIVE ESTERASE-CATALYZED HYDROLYSIS OF 2',3',5'-TRIESTERS

被引：18

作者：

BARALDI, PG

BAZZANINI, R

MANFREDINI, S

SIMONI, D

ROBINS, MJ

机构：

[1] UNIV FERRARA,DIPARTIMENTO SCI FARMACEUT,VIA FOSSATO DI MORTARA 17-19,I-44100 FERRARA,ITALY

[2] BRIGHAM YOUNG UNIV,DEPT CHEM,PROVO,UT 84602

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 19期

关键词：

2'-O-ACYL; BV ARAU; PIG LIVER ESTERASE; PYRIDINIUM BROMIDE PERBROMIDE;

D O I：

10.1016/S0040-4039(00)93411-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 1-(2,3,5-tri-O-acetyl-beta-D-arabinofuranosyl)-5-[2-(trimethylsilyl)-vinyl]uracil (3) with pyridinium bromide perbromide and deacetylation gave BVAraU (2). Pig liver esterase (EC 3.1.1.1) catalyzed the regioselective hydrolysis of 1-(2,3,5-tri-O-acyl-beta-D-arabinofuranosyl)uracil derivatives to their 2'-O-acyl monoesters.

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收藏

页码：3177 / 3180

页数：4

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