BASAL EXTRACELLULAR DOPAMINE IN THE NUCLEUS-ACCUMBENS DURING AMPHETAMINE WITHDRAWAL - A NO NET FLUX MICRODIALYSIS STUDY

被引：29

作者：

CRIPPENS, D

CAMP, DM

ROBINSON, TE

机构：

[1] UNIV MICHIGAN,DEPT PSYCHOL,ANN ARBOR,MI 48104

[2] UNIV MICHIGAN,NEUROSCI PROGRAM,ANN ARBOR,MI 48109

来源：

NEUROSCIENCE LETTERS | 1993年 / 164卷 / 1-2期

关键词：

STRIATUM; PSYCHOMOTOR STIMULANT; DRUG DEPENDENCE;

D O I：

10.1016/0304-3940(93)90878-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The basal extracellular concentration of dopamine in the nucleus accumbens was quantified using the 'no net flux' microdialysis method, in rats undergoing withdrawal from D-amphetamine. Rats were initially pretreated with saline, or an escalating dose amphetamine regimen known to produce a robust withdrawal syndrome, and extracellular dopamine was quantified 3 or 28 days after the last pretreatment injection. There was no effect of amphetamine pretreatment on the basal extracellular concentration of dopamine in the nucleus accumbens, or on the 'in vivo recovery' of dopamine, estimated by 'no net flux' microdialysis. It is suggested that amphetamine withdrawal is not necessarily accompanied by changes in the basal extracellular concentration of dopamine in the nucleus accumbens.

引用

页码：145 / 148

页数：4

共 15 条

[1] COCAINE AND OTHER STIMULANTS - ACTIONS, ABUSE, AND TREATMENT [J].