MUTAGENICITY AND CYTOTOXICITY OF BENZ[A]ANTHRACENE DIOL EPOXIDES AND TETRAHYDRO-EPOXIDES - EXCEPTIONAL ACTIVITY OF BAY REGION 1,2-EPOXIDES

被引：167

作者：

WOOD, AW

CHANG, RL

LEVIN, W

LEHR, RE

SCHAEFERRIDDER, M

KARLE, JM

JERINA, DM

CONNEY, AH

机构：

[1] HOFFMANN LA ROCHE INC, DEPT BIOCHEM & DRUG METAB, NUTLEY, NJ 07110 USA

[2] NIAMDD, CHEM LAB, BETHESDA, MD 20014 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1977年 / 74卷 / 07期

关键词：

D O I：

10.1073/pnas.74.7.2746

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：2746 / 2750

页数：5

共 34 条

[1] MAMMALIAN CELL GENETICS .2. CHEMICAL INDUCTION OF SPECIFIC LOCUS MUTATIONS IN CHINESE HAMSTER CELLS IN VITRO [J].

CHU, EHY ;

MALLING, HV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 61 (04) :1306-&

[2] FACILE SYNTHESIS OF ARENE OXIDES AT K-REGIONS OF POLYCYCLIC-HYDROCARBONS [J].

DANSETTE, P ;

JERINA, DM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (04) :1224-1225

[3] OXIDATION OF CARCINOGENS BENZO[A]PYRENE AND BENZO[A]ANTHRACENE TO DIHYDRODIOLS BY A BACTERIUM [J].

GIBSON, DT ;

MAHADEVAN, V ;

JERINA, DM ;

YAGI, H ;

YEH, HJC .

SCIENCE, 1975, 189 (4199) :295-297

[4] IDENTIFICATION OF MUTAGENIC METABOLITES OF BENZO[A]PYRENE IN MAMMALIAN-CELLS [J].

HUBERMAN, E ;

SACHS, L ;

YANG, SK ;

GELBOIN, HV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (02) :607-611

[5]

Jerina D.M., 1977, DRUG METABOLISM MICR, P13

[6]

JERINA DM, 1976, IN VITRO METABOLIC A, P159

[7] BENZO[A]PYRENE 7,8-DIHYDRODIOL IS MORE CARCINOGENIC THAN BENZO[A]PYRENE IN NEWBORN MICE [J].

KAPITULNIK, J ;

LEVIN, W ;

CONNEY, AH ;

YAGI, H ;

JERINA, DM .

NATURE, 1977, 266 (5600) :378-380

[8] (+/-)-7ALPHA,8BETA-DIHYDROXY-9BETA,10BETA-EPOXY-7,8,9,10-TETRAHYDROBENZO[A]-PYRENE IS AN INTERMEDIATE IN METABOLISM AND BINDING TO DNA OF BENZO[A]PYRENE [J].

KING, HWS ;

OSBORNE, MR ;

BELAND, FA ;

HARVEY, RG ;

BROOKES, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (08) :2679-2681

[9] ALKYLATION OF POLYGUANYLIC ACID AT 2-AMINO GROUP AND PHOSPHATE BY POTENT MUTAGEN (+1-)-7 BETA,8ALPHA-DIHYDROXY-9BETA,10BETA-EPOXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE [J].

KOREEDA, M ;

MOORE, PD ;

YAGI, H ;

YEH, HJC ;

JERINA, DM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (21) :6720-6722

[10]

LEHR RE, 1977, TETRAHEDRON LETT, P539

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