EFFECT OF HIGH-CARBOHYDRATE FEEDING WITH DEXTROSE OR SUCROSE ON ADIPOSE-TISSUE LIPOPROTEIN-LIPASE ACTIVITY AND PLASMA TRIGLYCERIDE LEVELS IN HEMODIALYSIS-PATIENTS

The actue effect of feeding high concentration carbohydrate meals containing equicaloric amounts of dextrose or sucrose on the activity of adipose tissue lipoprotein lipase and the concentration of plasma triglyceride was assessed in 11 hemodialysis patients. Dextrose feeding resulted in higher postprandial glucose levels and a greater insulin response than sucrose. The relationship between the postprandial change in the activity of adipose tissue lipoprotein lipase and the insulin response to feeding almost reached statistical significance (r(s)=0.40, P=0.08, n=20), and the increase in the activity of the enzyme after dextrose feeding was greater than after sucrose (P<0.01). There was a significant decrease in plasma triglyceride levels after dextrose feeding (P<0.01), but no change was observed after the ingestion of sucrose. These results indicate that the inability of the administered sucrose to raise the plasma insulin concentration to the same level as isocaloric amounts of dextrose probably accounts for the smaller increase in the activity of adipose tissue lipoprotein lipase after sucrose. The failure of plasma triglyceride levels to fall after sucrose feeding suggests that the extent to which the activity of adipose tissue lipoprotein lipase increases postprandially may be important in the regulation of triglyceride metabolism in hemodialysis patients.