BEHAVIORAL INTERACTIONS BETWEEN MUSCIMOL AND COMPOUNDS SELECTIVE FOR THE D1 AND D2 DOPAMINE RECEPTOR SUBTYPES

被引：8

作者：

ASIN, KE

BEDNARZ, LM

机构：

[1] Neuroscience Research Division, Pharmaceutical Discovery, Dept. 47H, Abbott Park, IL

来源：

NEUROSCIENCE LETTERS | 1990年 / 113卷 / 03期

关键词：

Catalepsy; D1; D2 receptor subtypes; Dopamine; GABA; Grooming; Stereotypy;

D O I：

10.1016/0304-3940(90)90599-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study investigated the effects of the GABA agonist muscimol on the behaviors produced by acute injections of selective D1 and D2 agonists and antagonists. Muscimol potentiated the intensity of stereotyped behaviors shown by rats treated with the D2 agonist quinpirole; in contrast, it suppressed the repetitive bouts of grooming shown by rats treated with SKF38393. Muscimol potentiated the catalepsy produced by either a D1 (SCH23390) or D2 (metoclopramide) antagonist, suggesting that the cataleptic behaviors produced by these compounds may contain a common GABAergic mechanism. © 1990.

引用

页码：286 / 291

页数：6

共 14 条

[1] DOPAMINE MAY INFLUENCE STRIATAL GABA RELEASE VIA 3 SEPARATE MECHANISMS [J].