IDENTIFICATION OF NEW METABOLITES OF BUTYLATED HYDROXYTOLUENE (BHT) IN RATS

被引：22

作者：

YAMAMOTO, K ^{[1
]}

TAJIMA, K ^{[1
]}

MIZUTANI, T ^{[1
]}

机构：

[1] KYOTO PREFECTURAL UNIV,FAC LIVING SCI,KYOTO 606,JAPAN

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1979年 / 2卷 / 03期

关键词：

2; 6-di-tert-butyl-4-[(methylthio)methyl]-phenol; 6-di-tert-butyl-p-benzoquinone; 6-di-tert-butylhydroquinone; butylated hydroxytoluene; GC-MS; mebolism; ring-oxygenated metabolites;

D O I：

10.1248/bpb1978.2.164

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The urinary and fecal excretion of three new metabolites of butylated hydroxytoluene (BHT) were revealed by gas chromatography after intraperitoneal administration of this compound to male Wistar rats. The structures of these metabolites, 2, 6-di-tert-butyl-p-benzoquinone (M-I), 2, 6-di-tert-butylhydroquinone (M-II), and 2, 6-di-tert-butyl-4-[(methylthio) methyl] phenol (M-III), were identified by comparison of gas chromatographic and mass spectral data with those of authentic samples. The possible formation of 2, 6-di-tert-butyl-4-hydroperoxy-4-methyl-2, 5-cyclohexadien-1-one (1) as an intermediary metabolite to account for the occurrence of M-I was also discussed. © 1979, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：164 / 168

页数：5

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