LOCALIZATION OF HUMAN CELL-CYCLE REGULATORY GENES CDC25C TO 5Q31 AND WEE1 TO 11P15.3-11P15.1 BY FLUORESCENCE INSITU HYBRIDIZATION

被引：27

作者：

TAVIAUX, SA ^{[1
]}

DEMAILLE, JG ^{[1
]}

机构：

[1] INSERM, U249, F-34033 MONTPELLIER, FRANCE

来源：

GENOMICS | 1993年 / 15卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1032

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The cell cycle control genes are highly conserved during evolution since they play a key role in the regulation of cell division. We have localized CDC25C and WEE1 respectively at 5q31 and 11p15.3-11p15.1 using fluorescent in situ hybridization of cDNA probes on human chromosomes. This shows that genes acting through a regulatory phosphorylation cascade are not clustered on the same chromosome. Furthermore, they appear to map on chromosomal regions involved in tumorigenesis. The 5q23-q31 region of chromosome 5 is deleted in some hematologic disorders, and the p15 region of chromosome 11 is involved in development of embryonic tumors. © 1993 Academic Press. All rights reserved.

引用

收藏

页码：194 / 196

页数：3

相关论文

共 26 条

[1] REDUCTION TO HOMOZYGOSITY OF GENES ON CHROMOSOME-11 IN HUMAN-BREAST NEOPLASIA [J].

ALI, IU ;

LIDEREAU, R ;

THEILLET, C ;

CALLAHAN, R .

SCIENCE, 1987, 238 (4824) :185-188

[2] SIMULTANEOUS LOCALIZATION OF COSMIDS AND CHROMOSOME R-BANDING BY FLUORESCENCE MICROSCOPY - APPLICATION TO REGIONAL MAPPING OF HUMAN CHROMOSOME-11 [J].

CHERIF, D ;

JULIER, C ;

DELATTRE, O ;

DERRE, J ;

LATHROP, GM ;

BERGER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6639-6643

[3] LOSS OF GENES ON THE SHORT ARM OF CHROMOSOME-11 IN BLADDER-CANCER [J].

FEARON, ER ;

FEINBERG, AP ;

HAMILTON, SH ;

VOGELSTEIN, B .

NATURE, 1985, 318 (6044) :377-380

[4] FISSION YEAST P107WEE1 MITOTIC INHIBITOR IS A TYROSINE SERINE KINASE [J].

FEATHERSTONE, C ;

RUSSELL, P .

NATURE, 1991, 349 (6312) :808-811

[5] SPECIFIC ACTIVATION OF CDC25 TYROSINE PHOSPHATASES BY B-TYPE CYCLINS - EVIDENCE FOR MULTIPLE ROLES OF MITOTIC CYCLINS [J].

GALAKTIONOV, K ;

BEACH, D .

CELL, 1991, 67 (06) :1181-1194

[6] WEE1+-LIKE GENE IN HUMAN-CELLS [J].

IGARASHI, M ;

NAGATA, A ;

JINNO, S ;

SUTO, K ;

OKAYAMA, H .

NATURE, 1991, 353 (6339) :80-83

[7]

KEMPER O, 1991, HUM GENET, V87, P623

[8] LOSS OF HETEROZYGOSITY IN 3 EMBRYONAL TUMORS SUGGESTS A COMMON PATHOGENETIC MECHANISM [J].

KOUFOS, A ;

HANSEN, MF ;

COPELAND, NG ;

JENKINS, NA ;

LAMPKIN, BC ;

CAVENEE, WK .

NATURE, 1985, 316 (6026) :330-334

[9]

KOUFOS A, 1989, AM J HUM GENET, V44, P711

[10] CLINICAL AND CYTOGENETIC CORRELATIONS IN 63 PATIENTS WITH THERAPY-RELATED MYELODYSPLASTIC SYNDROMES AND ACUTE NONLYMPHOCYTIC LEUKEMIA - FURTHER EVIDENCE FOR CHARACTERISTIC ABNORMALITIES OF CHROMOSOME-5 AND CHROMOSOME-7 [J].

LEBEAU, MM ;

ALBAIN, KS ;

LARSON, RA ;

VARDIMAN, JW ;

DAVIS, EM ;

BLOUGH, RR ;

GOLOMB, HM ;

ROWLEY, JD .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (03) :325-345