LIPID-PEROXIDATION AND ANTIOXIDANT ENZYMATIC SYSTEMS IN RAT RETINA AS A FUNCTION OF AGE

被引：60

作者：

CASTORINA, C ^{[1
]}

CAMPISI, A ^{[1
]}

DIGIACOMO, C ^{[1
]}

SORRENTI, V ^{[1
]}

RUSSO, A ^{[1
]}

VANELLA, A ^{[1
]}

机构：

[1] UNIV CATANIA,SCH PHARM,INST BIOCHEM,CHAIR BIOCHEM,VIALE ANDREA DORIA 6,I-95100 CATANIA,ITALY

来源：

NEUROCHEMICAL RESEARCH | 1992年 / 17卷 / 06期

关键词：

LIPOPEROXIDATION; ANTIOXIDANT ENZYMATIC SYSTEMS; RETINA; AGING;

D O I：

10.1007/BF00968789

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, we have assayed the enzymatic activity of Cu,Zn-SOD, Mn-SOD, GSH-Px, GSH-Red, Cat, and G6PD in rat retina as a function of age. Conjugated diene levels and MDA formation were also determined. The conjugated diene levels in rat retina were found to increase significantly with age, accompanied by a marked decrease in GSH-Px and Cat activities. No age-related change in MDA levels and in GSH-Red and G6PD activity was found, whereas a significant increase in SOD activity was observed between 1 and 4 months. Decreased GSH-Px and Cat activity is related to increased lipid peroxidation with age.

引用

页码：599 / 604

页数：6

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