INCREASED NEUROTOXICITY OF ARSENIC IN METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY

被引：44

作者：

BROUWER, OF

ONKENHOUT, W

EDELBROEK, PM

DEKOM, JFM

DEWOLFF, FA

PETERS, ACB

机构：

[1] UNIV HOSP LEIDEN, DEPT PEDIAT, DIV CHILD NEUROL, 2300 RC LEIDEN, NETHERLANDS

[2] UNIV HOSP LEIDEN, DEPT TOXICOL, DIV CHILD NEUROL, 2300 RC LEIDEN, NETHERLANDS

[3] DIAKONESSEN HOSP, DEPT PHARM, PARAMARIBO, SURINAME

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 1992年 / 94卷 / 04期

关键词：

HOMOCYSTINURIA; METHYLENETETRAHYDROFOLATE REDUCTASE; ARSENIC; NEUROTOXICITY;

D O I：

10.1016/0303-8467(92)90179-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 16-year-old girl from Surinam presented with mental deterioration and severe paraparesis with areflexia and bilateral Babinski signs. Laboratory examination showed a hyperhomocysteinemia that was caused by 5,10-methylene-tetrahydrofolate reductase (MTHFR) deficiency. In addition, urine samples contained large amounts of arsenic. An open bag with the pesticide copper acetate arsenite was found to be the source of exposure. In remethylation defects such as MTHFR deficiency, the concentration of methyldonors is severely reduced. As arsenic is detoxified by methylation, we suggest that the MTHFR deficiency in this girl might explain the fact that of all family members exposed to arsenic, only she developed severe clinical signs and symptoms of arsenic poisoning.

引用

页码：307 / 310

页数：4

共 10 条

[1] STUDY OF INORGANIC ARSENIC METHYLATION BY RAT-LIVER INVITRO - RELEVANCE FOR THE INTERPRETATION OF OBSERVATIONS IN MAN [J].