CLINICAL-TRIAL OF INDOMETHACIN IN ALZHEIMERS-DISEASE

被引：899

作者：

ROGERS, J

KIRBY, LC

HEMPELMAN, SR

BERRY, DL

MCGEER, PL

KASZNIAK, AW

ZALINSKI, J

COFIELD, M

MANSUKHANI, L

WILLSON, P

KOGAN, F

机构：

[1] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,VANCOUVER V6T 1W5,BC,CANADA

[2] UNIV ARIZONA,DEPT PSYCHOL,TUCSON,AZ 85721

来源：

NEUROLOGY | 1993年 / 43卷 / 08期

关键词：

D O I：

10.1212/WNL.43.8.1609

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a 6-month, double-blind, placebo-controlled study, 100 to 150 mg/d indomethacin appeared to protect mild to moderately impaired Alzheimer's disease patients from the degree of cognitive decline exhibited by a well-matched, placebo-treated group. Over a battery of cognitive tests, indomethacin patients improved 1.3% (+/-1.8%), whereas placebo patients declined 8.4% (+/-2.3%)-a significant difference (p < 0.003). Caveats include adverse reactions to indomethacin and the limited scale of the trial.

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页码：1609 / 1611

页数：3

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