OBESITY ASSOCIATED INSULIN-RESISTANCE OCCURS IN HYPOPITUITARY SUBJECTS

被引：6

作者：

PAGE, RCL

LEVY, J

TURNER, RC

机构：

[1] Diabetes Research Laboratories and Department of Endocrinology, Radcliffe Infirmary, Oxford

来源：

DIABETIC MEDICINE | 1994年 / 11卷 / 09期

关键词：

INSULIN RESISTANCE; HYPOPITUITARISM; OBESITY;

D O I：

10.1111/j.1464-5491.1994.tb00369.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The study aimed to assess the role of pituitary hormones in the relationship between insulin resistance and obesity. Twelve male subjects with hypopituitarism secondary to surgery for a non-functioning pituitary adenoma were recruited. Subjects were receiving replacement hormones. Fasting plasma samples were taken for insulin, C-peptide, glucose, and lipids. Body mass index and blood pressure were measured. In hypopituitary subjects on replacement therapy, a positive association between body mass index and fasting plasma insulin levels (r = 0.76, p<0.004) was similar to that found in normal subjects. In conclusion pituitary function does not have a direct role in determining the relationship between fasting plasma insulin, an index of insulin resistance, and obesity.

引用

页码：862 / 865

页数：4

共 18 条

[1]

Bagdade JD, Porte D., Bierman EL, The interaction of diabetes and obesity on the regulation of basal lipolysis in man, Diabetes, 18, pp. 759-772, (1967)

[2]

Perley MJ, Kipnis DM, Plasma insulin responses to glucose and tolbutamide of normal weight and obese diabetic and nondiabetic subjects, Diabetes, 15, pp. 867-874, (1966)

[3]

Matthews DR, Hosker JP, Rudenski AS, Bown EG, Naylor BA, Treacher D., Et al., Homeostasis Model Assessment (HOMA): Insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, 28, pp. 412-419, (1985)

[4]

Randle PJ, Garland PB, Newsholme EA, Hales CN, The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus, Ann NY Acad Sci, 131, pp. 324-333, (1965)

[5]

Bortz WM, Metabolic consequences of obesity, Ann Int Med, 71, pp. 833-843, (1969)

[6]

Kalkoff RK, Kim HJ, Cerletty J., Ferrou CA, Metabolic effects of weight loss in obese subjects: changes in plasma substrate levels, insulin and growth hormone responses, Diabetes, 20, pp. 83-91, (1971)

[7]

Groop LC, Saloranta C., Shank M., Bonadonna RC, Ferrannini E., de Fronzo RA, The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and non‐insulin‐dependent diabetes mellitus, J Clin Endocrinol Metab, 72, pp. 96-107, (1991)

[8]

Olefsky JM, Kolterman OG, Mechanisms of insulin resistance in obesity and non insulin dependent (type II) diabetes, Am J Med, 70, pp. 151-168, (1981)

[9]

Rohner-Jeanrenaud F., Jeanrenaud B., Involvement of the cholinergic system in insulin and glucagon oversecretion of genetic pre‐obesity, Endocrinology, 116, pp. 830-834, (1985)

[10]

Berthoud HR, Jeanrenaud B., Acute hyperinsulinaemia and its reversal by vagotomy after lesions of the ventromedial hypothalamus in anaesthetized rats, Endocrinology, 105, pp. 146-151, (1979)

← 1 2 →