PROGESTERONE SYNTHESIS AND MYELIN FORMATION BY SCHWANN-CELLS

被引:399
作者
KOENIG, HL
SCHUMACHER, M
FERZAZ, B
DOTHI, AN
RESSOUCHES, A
GUENNOUN, R
JUNGTESTAS, I
ROBEL, P
AKWA, Y
BAULIEU, EE
机构
[1] INSERM, U33, HORMONES LAB, F-94276 LE KREMLIN BICETRE, FRANCE
[2] UNIV BORDEAUX 1, DEV NEUROBIOL LAB, F-33405 TALENCE, FRANCE
[3] COLL FRANCE, CNRS, U1115, F-75231 PARIS, FRANCE
关键词
D O I
10.1126/science.7770777
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Progesterone is shown here to be produced from pregnenolone by Schwann cells in peripheral nerves, After cryolesion of the sciatic nerve in male mice, axons regenerate and become myelinated. Blocking either the local synthesis or the receptor-mediated action of progesterone impaired remyelination. Administration of progesterone or its precursor, pregnenolone, to the lesion site increased the extent of myelin sheath formation. Myelination of axons was also increased when progesterone was added to cultures of rat dorsal root ganglia. These observations indicate a role for locally produced progesterone in myelination, demonstrate that progesterone is not simply a sex steroid, and suggest a new therapeutic approach to promote myelin repair.
引用
收藏
页码:1500 / 1503
页数:4
相关论文
共 37 条
[1]  
AKWA Y, 1993, CR ACAD SCI III-VIE, V316, P410
[2]   ASTROCYTES AND NEUROSTEROIDS - METABOLISM OF PREGNENOLONE AND DEHYDROEPIANDROSTERONE - REGULATION BY CELL-DENSITY [J].
AKWA, Y ;
SANANES, N ;
GOUEZOU, M ;
ROBEL, P ;
BAULIEU, EE ;
LEGOASCOGNE, C .
JOURNAL OF CELL BIOLOGY, 1993, 121 (01) :135-143
[3]   CELL-DEATH AND CONTROL OF CELL-SURVIVAL IN THE OLIGODENDROCYTE LINEAGE [J].
BARRES, BA ;
HART, IK ;
COLES, HSR ;
BURNE, JF ;
VOYYODIC, JT ;
RICHARDSON, WD ;
RAFF, MC .
CELL, 1992, 70 (01) :31-46
[4]  
Baulieu E-E, 1981, STEROID HORMONE REGU, P3
[5]   NEUROSTEROIDS - A NEW FUNCTION IN THE BRAIN [J].
BAULIEU, EE .
BIOLOGY OF THE CELL, 1991, 71 (1-2) :3-10
[6]  
BIZZOZERO OA, 1991, J BIOL CHEM, V266, P17092
[7]   NEURONS REGULATE SCHWANN-CELL GENES BY DIFFUSIBLE MOLECULES [J].
BOLIN, LM ;
SHOOTER, EM .
JOURNAL OF CELL BIOLOGY, 1993, 123 (01) :237-243
[8]   GROWTH OF A RAT NEUROBLASTOMA CELL LINE IN SERUM-FREE SUPPLEMENTED MEDIUM [J].
BOTTENSTEIN, JE ;
SATO, GH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (01) :514-517
[9]  
CHADWICK D, 1990, CIBA F S, V153
[10]   NEUROSTEROIDS - 3-ALPHA-HYDROXY-5-ALPHA-PREGNAN-20-ONE AND ITS PRECURSORS IN THE BRAIN, PLASMA, AND STEROIDOGENIC GLANDS OF MALE AND FEMALE RATS [J].
CORPECHOT, C ;
YOUNG, J ;
CALVEL, M ;
WEHREY, C ;
VELTZ, JN ;
TOUYER, G ;
MOUREN, M ;
PRASAD, VVK ;
BANNER, C ;
SJOVALL, J ;
BAULIEU, EE ;
ROBEL, P .
ENDOCRINOLOGY, 1993, 133 (03) :1003-1009