QUINAZOLINES AND 1,4-BENZODIAZEPINES .44. FORMATION OF ISOINDOLES BY RING CONTRACTION OF 1-ALKYL-1,4-BENZODIAZEPINES

被引：16

作者：

FRYER, RI

EARLEY, JV

STERNBAC.LH

机构：

[1] Chemical Research Department, Hoffmann-La Roche, Inc., Nutley

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1969年 / 34卷 / 03期

关键词：

D O I：

10.1021/jo01255a037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Alkyl-substituted 2,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepin-2-ones of type 1 have been shown to undergo almost quantitative rearrangement to give N-alkyl-3-phenyl-1-isoindolecarboxamides of type 2 on treatment with base in nonaqueous media. A number of transformation products are described and possible mechanisms for the rearrangement are discussed. © 1969, American Chemical Society. All rights reserved.

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页码：649 / &

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