MORPHOLOGICAL-CHANGES IN THE ENDOCRINE PANCREAS IN PREGNANT RATS WITH EXPERIMENTAL DIABETES

被引：25

作者：

VANASSCHE, FA ^{[1
]}

AERTS, L ^{[1
]}

GEPTS, W ^{[1
]}

机构：

[1] VRIJE UNIV BRUSSEL,B-1050 BRUSSELS,BELGIUM

来源：

JOURNAL OF ENDOCRINOLOGY | 1979年 / 80卷 / 02期

关键词：

D O I：

10.1677/joe.0.0800175

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This present study has demonstrated that during normal pregnancy in the rat the number of β-cells is increased (hyperplasia) and the volume of the individual β-cells is increased (hypertrophy). During experimental diabetes, however, the endocrine pancreas has an impaired capacity to compensate during pregnancy. In the experimental diabetic pregnant rat the β-cells cannot replicate due to the unfavourable metabolic environment. This could reflect the complications caused by diabetes during human pregnancy.

引用

页码：175 / 179

页数：5

共 17 条

[1] ULTRASTRUCTURAL CHANGES OF ENDOCRINE PANCREAS IN PREGNANT RATS [J].

AERTS, L ;

VANASSCHE, FA .

DIABETOLOGIA, 1975, 11 (04) :285-289

[2]

Chalkley HW, 1943, J NATL CANCER I, V4, P47

[3]

EFF C, 1977, DIABETOLOGIA, V13, P391

[4]

GILLMER MDG, 1975, BRIT MEDICAL J, V3, P393

[5]

GREENSPAN HP, 1972, STUD APPL MATH, V51, P317

[6]

HELLMAN B, 1959, ACTA ENDOCRINOL-COP, V32, P92

[7]

HELLMAN B, 1960, ACTA OBSTET GYNECOL, V39, P317

[8]

Hoffman WS, 1937, J BIOL CHEM, V120, P51

[9]

Ivic M., 1959, Anatomischer Anzeiger, V107, P347

[10]

Logothetopoulos J, 1972, HDB PHYSL ENDOCRINOL, P67

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