ENHANCEMENT OF PERCUTANEOUS ABSORPTION BY USE OF VOLATILE - NONVOLATILE SYSTEMS AS VEHICLES

Using in vitro techniques the penetration of 14C labeled fluminolone acetonide and its acetate ester through human skin at 37° has been examined with vehicle mixtures of isopropanol and isopropyl myristate or propylene glycol. Little penetration was found from either of the nonvolatile solvents. As the formulation was changed to include increasing amounts of volatile component, however, penetration could be increased up to 8 to 10 times. Precipitation of steroid prevented greater increases. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company