PROMOTION OF LIVER-TUMORS BY STEROID-HORMONES

被引：11

作者：

DESSERWIEST, L

机构：

[1] Institute for Cancer Research, University of Vienna, Vienna

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1979年 / 5卷 / 2-3期

关键词：

D O I：

10.1080/15287397909529745

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Corticosterone inhibits proliferation of rat liver cells, but it can be inactivated by blocking its cytoplasmic receptors in liver cells with other steroids (progesterone). High levels of progesterones in animals lead to stimulated proliferation in the liver. Abnormally high proliferation in the liver may promote malignant transformation or may make it possible for smaller amounts of hepatocarcinogenic substances to induce tumors in a shorter time than normal. © 1979 by Hemisphere Publishing Corporation.

引用

页码：203 / 206

页数：4

共 18 条

[1]

ALPERT ME, 1968, LANCET, V1, P1265

[2] ORNITHINE DECARBOXYLASE ACTIVITY, NUCLEIC-ACIDS AND CELL TURNOVER IN LIVERS OF PREGNANT RATS [J].