LACK OF RESPONSE OF BONE-MARROW, INVITRO, TO GROWTH-FACTORS IN CONGENITAL NEUTROPENIA

被引：4

作者：

CHANG, J

CRAFT, AW

REID, MM

COUTINHO, LH

DEXTER, M

机构：

[1] ROYAL VICTORIA INFIRM,DEPT CHILD HLTH,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND

[2] ROYAL VICTORIA INFIRM,DEPT HAEMATOL,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND

[3] CHRISTIE HOSP & HOLT RADIUM INST,DEPT HAEMATOL,MANCHESTER M20 9BX,LANCS,ENGLAND

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1990年 / 35卷 / 02期

关键词：

congenital neutropenia; growth factors; marrow culture;

D O I：

10.1002/ajh.2830350212

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Severe congenital neutropenia has a poor outlook. In vitro clonogenic assays using recombinant growth factors may improve understanding of the underlying pathogenetic mechanisms and identify those in whom growth factors might be clinically useful. Marrow from a boy with congenital neutropenia was cultured with a variety of recombinant growth factors. The results show that the neutropenia did not result from a lack of myeloid progenitors but that these progenitors could not produce mature neutrophils. Bone marrow transplantation is being considered as the most likely approach to correct neutropenia. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：125 / 126

页数：2